| Year | Location | Surface | Round | Result | Score |
| 2004 | Stuttgart, Germany | Clay | QF | Lost | 3-6 7-6(3) 5-7 |
| 2005 | ATP Masters Series Miami, Florida, USA | Hard | SF | Won | 6-4 6-3 |
| 2005 | ATP Masters Series Rome, Italy | Clay | SF | Won | 4-6 6-4 7-5 |
| 2005 | Roland Garros, France | Clay | QF | Won | 7-5 6-2 6-0 |
| 2007 | Barcelona, Spain | Clay | SF | Won | 7-5 6-1 |
| 2007 | US Open, New York, USA | Hard | R16 | Lost | 7-6 6-4 6-7 2-6 |
| 2007 | ATP Tennis Masters Cup, Shanghai, China | Hard | RR | Lost | 6-4 4-6 3-6 |
| 2008 | ATP Masters Series Monte Carlo, Monaco | Clay | QF | Won | 6-1 7-5 |
| 2008 | Barcelona, Spain | Clay | W | Won | 6-1 4-6 6-1 |
| 2009 | Barcelona, Spain | Clay | W | Won | 6-2 7-5 |
| 2009 | ATP Masters Series Canada, Montreal, Canada | Hard | R32 | Won | 4-3 ret. |
| 2010 | ATP Masters Series Miami, Florida, USA | Hard | R16 | Won | 7-6(5) 6-4 |
| 2010 | ATP Masters Series Monte Carlo, Monaco | Clay | SF | Won | 6-2 6-3 |
| 2010 | ATP Masters Series Rome, Italy | Clay | W | Won | 7-5 6-2 |
| 2011 | Australian Open, Melbourne, Australia | Hard | QF | Lost | 4-6 2-6 3-6 |
| 2011 | ATP Masters Series Monte Carlo, Monaco | Clay | W | Won | 6-4 7-5 |
| 2011 | Barcelona, Spain | Clay | W | Won | 6-2 6-4 |
| 2012 | Barcelona, Spain | Clay | F | Won | 7-6(1) 7-5 |
| 2012 | ATP Masters Series Rome, Italy | Clay | SF | Won | 7-6(6) 6-0 |
| 2012 | Roland Garros, France | Clay | SF | Won | 6-2 6-2 6-1 |
| 2013 | Acapulco, Mexico | Clay | W | Won | 6-0 6-2 |
| 2013 | ATP Masters Madrid Open | Clay | QF | Won | 4-6 7-6(3) 6-0 |
| 2013 | ATP Masters Series Rome, Italy | Clay | QF | Won | 6-4 4-6 6-2 |
