| Year | Location | Surface | Round | Result | Score |
| 2006 | Roland Garros, France | Clay | QF | Won | 6-4 6-4 |
| 2007 | ATP Masters Series Indian Wells, California, USA | Hard | W | Won | 6-2 7-5 |
| 2007 | ATP Masters Series Miami, Florida, USA | Hard | QF | Lost | 3-6 4-6 |
| 2007 | ATP Masters Series Rome, Italy | Clay | QF | Won | 6-2 6-3 |
| 2007 | Roland Garros, France | Clay | SF | Won | 7-5 6-4 6-2 |
| 2007 | Wimbledon, England | Grass | SF | Won | 3-6 6-1 4-1 (ret) |
| 2007 | ATP Masters Series Canada, Montreal, Canada | Hard | SF | Lost | 5-7 3-6 |
| 2007 | ATP Tennis Masters Cup, Shanghai, China | Hard | RR | Won | 6-4 6-4 |
| 2008 | ATP Masters Series Indian Wells, California, USA | Hard | SF | Lost | 3-6 2-6 |
| 2008 | ATP Masters Series Hamburg | Clay | SF | Won | 7-5 2-6 6-2 |
| 2008 | Roland Garros, France | Clay | SF | Won | 6-4 6-2 7-6(3) |
| 2008 | Queens, London, England | Grass | W | Won | 7-6(6) 7-5 |
| 2008 | ATP Masters Series Cincinnati, Ohio, USA | Hard | SF | Lost | 1-6 5-7 |
| 2008 | Olympic Games Beijing, China | Hard | SF | Won | 6-4 1-6 6-4 |
| 2009 | Davis Cup ESP v SER, 1st RD, Benidorm, Spain | Clay | RR | Won | 6-4 6-4 6-1 |
| 2009 | ATP Masters Series Monte Carlo, Monaco | Clay | W | Won | 6-3 2-6 6-1 |
| 2009 | ATP Masters Series Rome, Italy | Clay | W | Won | 7-6(2) 6-2 |
| 2009 | ATP Masters Madrid Open | Clay | SF | Won | 3-6 7-6(5) 7-6(9) |
| 2009 | ATP Masters Series Cincinnati, Ohio, USA | Hard | SF | Lost | 1-6 4-6 |
| 2009 | ATP Masters Series Paris, France | Hard | SF | Lost | 2-6 3-6 |
| 2009 | ATP World Tour Finals, London | Indoor Hard | RR | Lost | 6-7(5), 3-6 |
| 2010 | US Open, New York, USA | Hard | W | Won | 6-4 5-7 6-4 6-2 |
| 2010 | ATP World Tour Finals, London | Indoor Hard | RR | Won | 7-5 6-2 |
| 2011 | ATP Masters Series Indian Wells, California, USA | Hard | F | Lost | 6-4 3-6 2-6 |
| 2011 | ATP Masters Series Miami, Florida, USA | Hard | F | Lost | 6-4 3-6 6-7(4) |
| 2011 | ATP Masters Madrid Open | Clay | F | Lost | 5-7 4-6 |
| 2011 | ATP Masters Series Rome, Italy | Clay | F | Lost | 4-6 4-6 |
| 2011 | Wimbledon, England | Grass | F | Lost | 4-6 1-6 6-1 3-6 |
| 2011 | US Open, New York, USA | Hard | F | Lost | 2-6 4-6 7-(3) 1-6 |
| 2012 | Australian Open, Melbourne, Australia | Hard | F | Lost | 7-5 4-6 2-6 7-6(5) 5-7 |
| 2012 | ATP Masters Series Monte Carlo, Monaco | Clay | F | Won | 6-3 6-1 |
| 2012 | ATP Masters Series Rome, Italy | Clay | W | Won | 7-5 6-3 |
| 2012 | Roland Garros, France | Clay | W | Won | 6-4 6-3 2-6 7-5 |
| 2013 | ATP Masters Series Monte Carlo, Monaco | Clay | F | Lost | 2-6 6-7(1) |
